His career in the music began as a "cantorcico" (child singer) of the Cathedral of the Seville. He was a pupil of his brother, Pedro, of Fernández Castilleja and of Cristóbal de Morales.

His professional life centered around the Cathedrals of Jaén (1546), Seville (1548), Málaga (1554) and again Seville in 1555. Guerrero achieved great celebrity both inside of and outside of Spain, and he was able to have many of his works published in France, Italy and Flanders.

The theorist, Cerone, compared him with the Flamenco composer Orlando di Lasso. This is an indication the esteem in which he was held. His polyphony closely resembles that of Morales: coloristic, transparent and of a great lyricism.

It is spiritual and mystical. He said himself that the only thing he sought with his music was to enlighten souls and not to induce flattery. Among his significant works are some 20 masses, more than 100 motets, a magnificat book and his delightful songs and spiritual villanescas "Canciones y Villanescas Espirituales." We also find some of his secular works in the Songbook of Medinaceli. http://classicalmus.hispeed.com