Thanks to the dedicatory of the book we know that he worked for Francisco de Zúñiga.

The book has seven parts, that contain fugues or fugas (word that appears at first time in a practical music book), contrapuntos, sonetos, bajas, vacas, discantes, pavanas, proverbios, canciones, romances and villancicos, ordered by level of difficulty, and it includes pieces for two vihuelas, for vihuela and another instrument, or for vihuela and voice.

The production of Valderrábano is very important for the knowledge of the vihuela music in the Spanish Renaissance of the Sixteenth Century, and in general for a better knowledge of European instrumental music, because Valderrábano includes transcriptions of pieces of Morales, Josquin, Gombert, Verdelot, Sepúlveda, Layole, Willaert, Ruffo, Ortiz, Vasquez, Milanés, Enríquez, Mouton y Bauldoin, between other composers of his time.