Her career as a soloist has led her to sing under the direction of many noted conductors, such as Gardiner, MalgoireKoopman, Leonhardt, Sigiswald Kuijken, and René Jacobs.

Agnès Mellon has performed in some of the world’s most prestigious concert venues, such as the Opéra de Paris, the Théatre des Champs-Elysées, the Salle Pleyel, Carnegie Hall, as well as the Amsterdam’s Concertgebow and Opera and numerous halls in Japan. Agnès Mellon created her own ensemble "Barcarole " with harpsichordist Kenneth Weiss and can be thus given to her passion: chamber music with voice. She is accompanied, in her recitals of Lieder and French melodies by various pianists: Claude Lavoix, Jean-François Heisser, Marie-Joseph Jude, Billy Heidi, François Kerdoncuff, Christian Ivaldi and Laure Colladant with the pianoforte. Her discography (over a hundred recordings) covers a broad repertoire.

She is frequently invited as a guest of the academy of French Music in Kyoto, where she gives masterclasses with the professors of the CNSM of Paris.