With a repertoire spanning three centuries, she has been hailed not only as the "supreme Handel soprano of our age" but also she is praised for her performances of works by composers as diverse as Mahler, Mozart, Schubert, and Schoenberg.

She works closely with such conductors as Pinnock, Hogwood, Gardiner, and Norrington and has sung with the Phiharmonia Orchestra, City of Birmingham Symphony Orchestra, St. Luke’s Orchestra of New York, Toronto and Montreal Symphony Orchestras, Sydney and Melbourne Symphony Orhcestras and the NACO Orchestra. In opera, concert, and recital she has appeared at many leading festivals including Aix-en-Provence, Mostly Mozart, and the BBC Proms. Her large discography includes Bach’s St. John Passion, B Minor Mass, Magnificat, and Christmas Oratorio with Gardiner, Purcell’s King Arthur and Haydn Masses with Pinnock and Hickox, Mozart’s Requiem, Magic Flute (First Lady), and Don Giovanni (Zerlina) with Norrignton, and a live recording of Mozart’s Così fan tutte (Despina) with Kuijken. She has recorded Schubert Lieder, Scarlatti Cantatas and two discs of Bach Solo Cantatas. Her disc of Purcell songs and airs, O Solitude, was honoured with a Classic CD Award in the "Bach and Before" category.

Born and raised in Canada, Nancy Argenta now lives in England.