She has enjoyed a particular prolific recording and concert activity performing worldwide with most of the prestigious conductors on the baroque scene and their attached orchestras, for example: Frans Brüggen with the Orchestra of the XVIIIth century, Jordi Savall and Hesperion XX, René Jacobs and Concerto Vocale, Robert King with The King's Consort, Chiara Banchini and Ensemble 415, Chistophe Coin with the Ensemble Baroque de Limoges, Philippe Herreweghe, Gustav Leonhardt and Nikolaus Harnoncourt with both the Vienna Philharmonic Orchestra and Concentus Musicus. She recently toured Australia with the Australian Brandeburg Orchestra and has been invited to perform with the Akademie für Alte Musik Berlin, Il Fondamento, the Norwegian Chamber Orchestra and the Gulbenkian Orchestra.

She is a co-founder of the vocal quartet La Colombina which specialises in Spanish and South American Renaissance Music and with whom she performs at major festivals worldwide. She has also formed Concerto Soave, with harpsichordist Jean-Marc Aymes, which mainly performs early XVIIth century Italian music. Their recordings for Harmonia Mundi - Monteverdi's Pianto della Madonna, Canta la Maddalena, Scarlatti's Cantatas and, more recently, Sigismondo d'India's Madrigali e Canzonette - were all released to great critical acclaim.

In Opera, her repertoire encompasses works by Monteverdi (L’Incoronazione di Poppea, Orfeo, Il Ritorno di Ulisse), Telemann (Orpheus), Purcell (Dido and Eneas), Blow (Venus y Adonis), Glück (Orphée et Euridice), Vivaldi (Dorilla in Tempe), Cavalli (Giasone), Cesti (L’Orontea), Haydn (Orlando Palladino); she has also recorded most of these works.

One of Maria Cristina Kiehr’s fundamental artistic activities is to discover and re-create lost or unknown scores. Consequently, she has world-premiered works by Giovanni Felice Sances, Fanny Hensel and by the living composer Alexander Müllenbach.