He then studied for five years with Jascha Heifetz in Los Angeles, the only violinist in whom Heifetz invested a long period of close personal guidance. On his return to Paris, he was immediately engaged by Sir Georg Solti for performances of the Berg Violin Concerto with the Orchestre de Paris, launching him on an international career during which he has performed with many of the world's leading conductors and orchestras.

Pierre Amoyal's worldwide success in a broad repertoire from Bach to his remarkable performances of concertos by Berg, Schoenberg, and the new Dutilleux Concerto has led to performances with conductors such as von Karajan, Ozawa, Maazel, Solti, Pretre, Fruhbeck de Burgos, Roshdestvensky, Sanderling, Dutoit, and Boulez. He is an annual guest with the major French orchestras and also appears throughout Italy, Germany, Holland, Belgium, Switzerland, Scandinavia, and Great Britain. In North America, Pierre Amoyal has had notable successes with the orchestras of Boston, Cleveland, Pittsburgh, Baltimore, and Detroit, and throughout Canada. In March 1985, he made his recital debut at Carnegie Hall to outstanding critical acclaim.

Highlights of the 1997-98 season include an opening season concert with the BBC Symphony in London, a tour of Japan and France with the Yomiuri Nippon Symphony a tour in Israel with the Israel Sinfonietta, concerts in Sweden, Italy, France, and Canada, and recitals in London, Milan, and Tokyo.

Pierre Amoyal was nominated at a very young age as a professor at the National Conservatory in Paris and now teaches at the Lausanne Conservatory. He is the artistic director of the Lausanne Summer Music Academy devoted exclusively to the violin/piano repertoire, which he originated in 1991 with Alexis Weissenberg. He plays the "Kochanski" Stradivarius (1717), which was miraculously recovered after its theft in Italy in 1987, and uses Peccate bows, c. 1800-50, after Tourte.